Nouvelle piste - veines et SEP - CCSVI - IVCC

[simplex]

Salut

Ici, les derniers informations (suite à notre rencontre à Lausanne).

Vidéo couleur doppler ultrasonographie (examen CCSVI). Même si c'est en anglais c'est une très bonne explication, les images suffisent :
http://www.youtube.com/watch?v=C_RXs5dPh6E

Introduction à la CCSVI :
Introduction à la sclérose en plaques d'origine veineuse

Forum CCSVI allemand (pour les informations Suisses) :
http://csvi-ms.net/forum
(Il y a déjà des personnes avec des examens et des traitements.)

Forum CCSVI anglais (This Is MS, TIMS) :
http://www.thisisms.com/forum-40.html
(Il y a déjà des personnes avec des examens et des traitements.)

Site web sur CCSVI avec beaucoup des liens :
http://csvi-ms.net/fr
(Les parties anglaises et allemandes ont plus de contenu.)

Pour les personnes qui s'intéresse à la recherche. Tous les articles importants sont téléchargeable (full text). Les articles les plus importants sont écrits en gras :
Publications sur la sclérose en plaque d'origine veineuse

On trouve dans le document de Dr. Marian Simka des images sur les différentes types des sténoses (obstacles) avec refluxes :
http://csvi-ms.net/files/multiple%20sclerosis-USG.pdf

Mon examen IRM SWI de fin octobre 09 aux CHUV. Le rapport est en français :
http://csvi-ms.net/forum/viewtopic.php?f=2&t=4#p2017

Une nouvelle étude très importante aux États-Unis avec 1700 personnes sur CCSVI (University at Buffalo, The State University of New York) :
Neurologists Investigate Possible New Underlying Cause of MS
Traduction Google en français

Si vous avez des questions ou des commentaires, je serais heureux de vous servir.

A+,
simplex

[simplex]

Salut

Société canadienne de la sclérose en plaques :
Étude sur la circulation sanguine dans le cerveau et l’insuffisance veineuse chez les personnes atteintes de SP

D'autres articles dans les médias :
http://csvi-ms.net/fr/content/media-coverage

A+,
simplex

[cocobidet]

merci pour toutes ces infos, il est toujours bon d'avoir des "tuyaux"

[simplex]

Salut

La SEP veineuse (CCSVI) est discutée en France sur le forum ARSEP :

http://www.arsep.org/phpBB3/viewtopic.php?f=3&t=1620

A+,
simplex

[simplex]

Salut

Je ne sais pas si ça intéresse quelqu'un.

Mais, un autre article de Prof. P. Zamboni est disponible. Je ne suis pas capable de traduire ce texte en français. L'allemand était déjà pénible.
Mais peut-être il y a quelqu'un qui comprend.

Multiple sclerosis (MS) is primarily an autoimmune disorder of unknown origin. This review focuses iron overload and oxidative stress as surrounding cause that leads to immunomodulation in chronic MS. Iron overload has been demonstrated in MS lesions, as a feature common with other neurodegenerative disorders. However, the recent description of chronic cerebrospinal venous insufficiency (CCSVI) associated to MS, with significant anomalies in cerebral venous outflow hemodynamics, permit to propose a parallel with chronic venous disorders (CVDs) in the mechanism of iron deposition. Abnormal cerebral venous reflux is peculiar to MS, and was not found in a miscellaneous of patients affected by other neurodegenerative disorders characterized by iron stores, such as Parkinson's, Alzheimer's, amyotrophic lateral sclerosis. Several recently published studies support the hypothesis that MS progresses along the venous vasculature. The peculiarity of CCSVI-related cerebral venous blood flow disturbances, together with the histology of the perivenous spaces and recent findings from advanced magnetic resonance imaging techniques, support the hypothesis that iron deposits in MS are a consequence of altered cerebral venous return and chronic insufficient venous drainage.

Singh, A. V. and Zamboni, P.: Anomalous venous blood flow and iron deposition in multiple sclerosis
J Cereb Blood Flow Metab, 2009/09/02/online Abstract

A+,
simplex

[simplex]

Salut

Joan/cheerleader de TIMS a copié le press release et elle a ajouté quelques commentaires en () parenthèses.

Press Release- A good summary of event in Bologna en anglais
Bits & Pieces rund um Bologna en allemand

Press Release Fondazione HILARESCERE

Moi, je ne vais pas traduire ce texte en français. C'est trop dur pour moi. Peut-être quelqu'un est motivé.
Autrement : http://translate.google.ch/?hl=en#

Un détail : Giulio Gabbiani est professeur à Genève.

A+,
simplex

____________________________________________________________

PRESS RELEASE
Bologna, Tuesday Sept. 8, 2009
FONDAZIONE HILARESCERE
Venous Function And Multiple Sclerosis
International Coterie

Four main points concerning the relationship between CCSVI and MULTIPLE SCLEROSIS were covered by several experts at a Meeting in Bologna. All the investigations that gave an answer to these 4 fundamental points were coordinated by Prof Paolo Zamboni who discovered CCSVI and its association with Multiple Sclerosis; in some other cases, research was carried out in cooperation between Prof Zamboni and major foreign Universities.
1) What is the origin of the extracranial cerebral vein stenoses which characterize CCSVI?
2) Are there advanced diagnostic systems capable of identifying which changes are caused by CCSVI in the central nervous system?
3) Can CCSVI be treated and how?
4) Can CCSVI therapy improve the clinical outcomes of MS and affect its prognosis?


Venous Function And Multiple Sclerosis is an international coterie of experts who met in Bologna on September 8 to discuss these issues from the perspective of neurologists – who have developed the scientific body of knowledge on MS – and the vascular and neurological surgeons who have further investigated these topics following the discovery of CCSVI. All investigations were coordinated by Professor Paolo Zamboni who discovered CCSVI and its association with multiple sclerosis.
This first study was conducted by an Italian research team composed of the vascular surgeons’ group headed by Professor Paolo Zamboni from the University of Ferrara and the neurologists’ group from the Department of Neurosciences of the Bellaria Hospital in Bologna headed by Dr. Fabrizio Salvi.
Fondazione Hilarescere is a foundation specially set up to provide adequate means and resources for research into medical and scientific insights aimed at fully understanding and curing diseases which are still partly unknown.
Fondazione HILARESCERE, chaired by Professor Fabio Roversi-Monaco, was set up on an initiative of Fondazione Cassa di Risparmio in Bologna.


THE MOST IMPORTANT ANSWER OF ALL:
endovascular therapy has led to a decrease in the number of disease relapses, a marked reduction in the number of active brain and spinal lesions and also a clear-cut improvement in the patients’ quality of life.
Prof. Paolo Zamboni headed a study where, together with Dr. Fabrizio Salvi, he was able to show that in patients with the clinical form of Relapsing-Remitting MS – which is the most common – there is a drop in the number of active lesions which persists up to 18 months after surgery. The percentage of active lesions falls from 50% to 12%, thus showing that the additional treatment of CCSVI reduces the aggressiveness of the disease. This finding is further confirmed by the number of patients who showed no relapses after endovascular surgery. In the 2 years before surgery, acute multiple sclerosis attacks were found in 50% of the recruited patients, while in the 2 years following surgery 73% of the patients had no more attacks, with a change in the clinical course of the disease. In all these patients also cognitive and motor activities – assessed by means of an outcome measure called MSFC - are significantly and persistently improved while the same is not true for patients with the progressive forms of the disease. In the latter, however, progression was stopped and the patients’ quality of life improved.
________________
The experts discussed, provided data and gave an answer to all 4 fundamental questions:
1) What is the origin of the extracranial cerebral vein stenoses which characterize CCSVI?
3 scientists answered this question from different perspectives: Professor Byung B. Lee, Georgetown University School of Medicine di Washington DC, showed that the malformations found in CCSVI are (MIGHT BE, IN MY OPINION) congenital truncular malformations which therefore certainly precede the development of Multiple Sclerosis. For this reason they cannot be regarded as a consequence of Multiple Sclerosis. Prof. Lee showed in which phases of the venous system development the malformations observed in CCSVI may appear. Byung B. Lee is the Chairman of the World Consensus Conference which gathers vascular experts from 47 countries and recently approved a scientific update on venous malformations in Montecarlo. (1)
Professor Giulio Gabbiani, Centre Médical Universitaire de Genève, demonstrated that there are no auto-immune phenomena in diseased veins thus excluding that the malformations found in CCSVI result from Multiple Sclerosis. (THIS WAS THE CHICKEN/EGG CLINCHER) He showed the results of a study which provides a histologic comparison between the walls of the veins affected by CCSVI-MS and those of normal subjects. Furthermore, at molecular level, CCSVI veins are structurally different from those of the control subjects, thus confirming the approach of the Montecarlo Consensus Conference. Prof. Gabbiani is one of the most important world experts in microscopic vessel wall morphology. (2)

The third presentation was about whether – genetically speaking – these malformations have any correlation with the findings so far obtained from the genetic study of MS. Prof. Alessandra Ferlini, Director of the Institute of Genetics at the University of Ferrara, discussed this point by presenting the promising results of a pilot study. (3) (THIS DISCUSSION WAS SO OVER MY HEAD, I FELT RETARDED, BUT THEN DR. D TOLD ME HE HAD TROUBLE WITH IT, AND I FELT MUCH BETTER....)

2) Are there advanced diagnostic systems capable of identifying which changes are caused by CCSVI in the central nervous system?
This is the second question addressed at the Meeting. Professor Mark Haacke, Director of the MRI Istitute for Biomedical Research in Detroit (4,5,6) and Professor Bianca Weinstock-Guttman, Neurologist at the Jacobs Neurological Institute (7) showed new magnetic resonance (MRI) parameters linked to CCSVI which might in the future bring about a true revolution in the way of diagnosing MS. These new parameters include: quantification of iron deposits and volume assessment of intracranial veins and CSF. (THIS PRESENTATION WAS FAN FRICKIN-TASTIC, AND BROUGHT IT ALL HOME....HAACKE IS BRILLIANT, HE INVENTED SWI TECHNOLOGY)

3) The third question that was answered at the Meeting was: Can CCSVI be treated and how? Innovative minimally-invasive endovascular repair techniques were discussed on account of the findings obtained by Dr. Roberto Galeotti (8), Head of the Interventional Radiology Section at the University Hospital of Ferrara who was the first in the world to perform this type of surgery, and Dr. Michael Dake, Chief of Cardiovascular and Interventional Radiology at Stanford University School of Medicine (California), who was the first to treat CCSVI outside Italy.
The most important finding is safety. At 2-year follow-up no major complications were observed. All surgical procedures were performed on a day hospital basis. Statistically, this treatment decreases pressure in the cerebral veins in a highly significant way, thus showing its enormous anti-inflammatory potential. (8)
The risk of re-stenosis is 16 times higher in the jugular veins than in the azygos vein, thus pointing to the need for more sophisticated and efficient tools to approach the former. Research will make such tools available during 2010. (THIS IS BASED ON LIBERATION PROCEDURE, NOT STENTING....THE JUGS WANT TO CLOSE BACK DOWN...ZAMBONI IS LOOKING INTO STENTING AND OPEN SURGERY FOR THE NECK.)

4) The fourth and fundamental point is whether CCSVI therapy can improve the clinical conditions of MS and affect its prognosis.
Dr. Fabrizio Salvi from the Bellaria Hospital in Bologna was the first Neurologist who studied the clinical correlations of CCSVI treatment in MS patients together with Prof. Paolo Zamboni. The patients enrolled in this study were 120 from all clinical classes, but only the results of the 65 subjects who are over 18 months from surgery will be reported in order to describe the outcome with the greatest possible accuracy. Generally speaking, patients treated with endovascular therapy showed a decrease in the number of disease relapses, a marked reduction in the number of active brain and spinal lesions and also a clear-cut improvement in the patients’ quality of life. The findings of this investigations will soon be published in detail on the Journal of Vascular Surgery (8). (SHOW ME THE MONEY!!!! I WANT NUMBERS, PEOPLE!)

Finally, Dr. Robert Zivadinov, Jacobs Neurogical Institute di Buffalo, discussed the results of a revolutionary pilot study performed last year where both American and Italian patients were blindly assessed in the USA by means of advanced MRI technology, then submitted to vascular surgery in Italy and followed up during the following year (9). This study was defined by the patients who volunteered to participate as the study of the 50,000 miles for treatment, because of the many trips they had to take overseas. This study was sponsored by Fondazione Hilarescere.

References

1. World Consensus Conference on Venous Malformations, Montecarlo September 4th 2009. This document was approved by experts from 47 different countries and will be published on all most important vascular surgery journals.
2. G. Gabbiani, M. Coen, F. Mascoli, P. Zamboni. Manuscript in preparation.
3. A. Ferlini, M. Bovolenta, M. Neri, F. Gualandi, A.Yuryev, F. Salvi, A. Liboni and P. Zamboni. Manuscript in preparation.
4. Haacke EM, Makki M, Ge Y, Maheshwari M, Sehgal V, Hu J, Selvan M, Wu Z, Latif Z, Xuan Y, Khan O, Garbern J, Grossman RI. Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging. J Magn Reson Imaging. 2009;29:537-44.
5. A. V. Singh and P. Zamboni Anomalous venous blood flow and iron deposition in multiple sclerosis. J Cereb Blood Flow Metab. 2009 Sep 2. [Epub ahead of print]
6. P. Zamboni, E. Menegatti, B. Weinstock-Guttman, C. Schirda, J. L. Cox, A. M. Malagoni, D. Hojnacki, C. Kennedy, E. Carl, M. G. Dwyer, N. Bergsland, R. Galeotti, Sara Hussein, I. Bartolomei, F. Salvi, R. Zivadinov. The severity of altered venous haemodynamics is related to CSF dynamics in chronic cerebrospinal venous insufficiency Submitted To Current Neurovascular Research
7. P. Zamboni, E. Menegatti, B. Weinstock-Guttman, C. Schirda, J. L. Cox, A. M Malagoni, D. Hojnacki, C. Kennedy, M. G. Dwyer, N. Bergsland, R. Galeotti, I. Bartolomei, F. Salvi, M. Ramanathan, R. Zivadinov. Csf flow and brain volume in multiple sclerosis are associated with altered cerebral venous doppler haemodynamics. Study presented at the European Multiple Sclerosis Congress ECTRIMS Düsseldorf, 9-12 September 2009
8. P. Zamboni, R. Galeotti; E. Menegatti; A. M. Malagoni, S. Gianesini, I. Bartolomei, F. Mascoli, F. Salvi Endovascular treatment of chronic cerebrospinal venous insufficency. A prospective opern-label study. Journal of Vascular Surgery, 2009, in press.
9. P. Zamboni, R. Galeotti, B. Weinstock-Guttman, G. Cutter, E. Menegatti, A. M. Malagoni, D. Hojnacki, J. L. Cox, C. Kennedy, I. Bartolomei, F. Salvi, R. Zivadinov Endovascular Treatment for Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis . A longitudinal pilot study. Study presented at the European Multiple Sclerosis Congress ECTRIMS Düsseldorf, 9-12 September 2009

Bologna, 8 September 2009
Press Office: Laboratorio delle idee – Francesca Rossini –
Tel.+39-051-273861 – cell.+39-331-6752354 e +39-335-5411331 labidee.ufficiostampa@labidee.it

[Françoise]

Simplex, intéressant...

[Petiote 66]

grand merci Simplex

Bisou

[simplex]

Salut

La version française existe :
Sclérose en plaques veineuse | CCSVI

A+,
simplex

[simplex]

Salut

Quel qu'un a lu les articles originaux de Zamboni ou regardé sur le forum TIMS?

Cela vaut la peine.

Qu'est-ce que vous en pensez?

Il y a aussi un nouveau site allemand avec forum : http://csvi-ms.net/
Les traductions en français sont en préparation.

simplex

[simplex]

La fondation Hilarescere organise une conférence le 8 septembre sur le sujet CCSVI à Bologna en Italie.

Le contenu: 08.09.2009 Bologna PDF

Quel qu'un de l'université Genève fait aussi une présentation.

Les résultats m'intéresse beaucoup!

A+,
simplex

[Fight]

Merci aussi, Simplex, je n'avais non plus entendu parler d'un rapport possible entre veines et SEP. Vraiment étrange!

[Petiote 66]

Merci Simplex pour ton post, j'avais jamais entendu parler de ces recherches qui me semblent prometteuses.

Bonne journée. bisou.

[Françoise]

Merci Simplex pour toutes ces informations.
Jamais entendu parler... Faut dire que je ne cherche plus tellement
Mais cela semble très prometteur.
Peut-être un jour saura-t-on la clé de tous ces mystères qui entourent la SEP...

[sté]

Merci pour ton post Simplex, ça prouve que la recherche avance, et l'idée qu'un jour on trouvera pourquoi et comment soigner m'aide à avancer.

[simplex]

Salut

Comme tous les "nouveaux" je cherche et je lis.

Dans les forums allemands et anglais il y a un sujet remarquable: les études de Prof. Zamboni d'Italie sur Chronic Cerebrospinal Venous Insufficiency (CCSVI). Il a commencé avec ses recherches en 2006. Dans ces études, il cherche le lien entre les veines et les plaques. Récemment, il a publié des résultats très intéressants.

Voici un résumé avec les informations clé:

• Il a trouvé une forte relation entre les veines du cou et de la poitrine et la SEP. Dans un groupe de 65 patients SEP et de 235 personnes contrôles (sans SEP), 86% des personnes SEP avaient des problèmes dans la veine v. azygos et 91% des personnes SEP avaient des problèmes dans la veine v. jugularis interna. Mais aucune personne dans le groupe contrôle! Ces problèmes de veines se manifestent sous forme de sténoses et de reflux. (Zamboni 2009)
• L'année passée, il a commencé à opérer les veines de ces personnes avec un ballon de dilatation. Ces personnes ont eu quatre fois moins des poussées que l'année précédente. (Zamboni CX 2009)
• Il a traité 18 personnes avec une poussée fraîche. Les symptômes ont disparus dans un intervalle de 4h à 4 jours. (Zamboni CX 2009)
• Toutes les personnes opérées qui ont eu par la suite une nouvelle poussée, ont également connu à nouveau des problèmes de veine (re-sténoses). (Zamboni CX 2009)

Il suppose que ces problèmes de veine sont probablement la cause de la SEP. Il va tenter de le démontrer dans sa prochaine recherche.
Moi, je trouve ces études très intéressantes. Malheureusement, il n'y aucune publication en français sur ce sujet, seulement en anglais ou en allemand.

Ici, suit une collection de liens sur ce sujet:

• Forum américain, aussi avec des patients opérés par le Dr. Dake, Standford University:
  http://www.thisisms.com/forum-40.html
• Un forum allemand, par exemple:
  http://www.ms-forum-weihe.de/forum/mix_ ... scasc=DESC

Les articles originaux de Zamboni:

• "Rationale and preliminary results of endovascular treatment of multiple sclerosis, the liberation procedure", 2009
  in "1978-2009 -31 years- Vascular and Endovascular Controversies Update" 31° International Symposium - CX Charing Cross, pp. 71-79
  http://www.fondazionehilarescere.org/pdf/CX.PDF
• Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis
  http://www.pubmedcentral.nih.gov/articl ... id=2647682
  J Neurol Neurosurg Psychiatry. 2009 April; 80(4): 392–399.

La fondation pour la recherche de Zamboni avec tous les publications de Zamboni sur CCSVI:
http://www.fondazionehilarescere.org/

Il y a aussi d’autres équipes qui travaillent sur ce sujet:

• Dr. Paolo Zamboni, University of Ferrera, Italy
• Dr. Michael Dake, Stanford University, California
• Dr. Marian Simka, Department of Angiology, Private Healthcare Institution SANA, Pszczyna; Poland
• Dr. Claude Franceschi, Hospital Saint Joseph and Pitié- Salpétrière, Paris, France
• Dr. Franz A. Schelling, http://www.ms-info.net

Le modèle pour CCSVI est la maladie chronic venous insufficiency (CVI) dans les jambes. Les varices peuvent se développer jusqu’en CVI. (http://fr.wikipedia.org/wiki/Varice) Il y des similarités remarquables:

• Facteur risque: La maladie CVI est deux fois plus fréquente chez les femmes que les hommes.
• Patho-physiologie: Ces problèmes de veines provoquent des inflammations avec des leucocytes.
• Cette maladie se développe en 3 étapes:
  
  1. Œdème réversible
  2. Œdème irréversible
  3. Ulcus cruris

Avez-vous déjà entendu parler de cette recherche? Qu'est-ce que vous en avez pensé?

A+,
simplex